HIV-1 latency; osteoclast differentiation; granulocytic differentiantion
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
innate immune responses
innate immune responses
skeletal muscle proliferation and differentiation; heart development and physiology
proliferation of breast cancer cells; growth of MYCN-amplified and therapy-resistant neuroblastoma
apoptosis; E2F1 protein regulation
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
SCN; circadian clock regulation
T cell leukaemia; MYCN target
E2F1 posttranscriptional regulation; E2F1 posttranscriptional regulation; development of TGFbeta resistance in gastric cancerp
proliferation of breast cancer cells; growth of MYCN-amplified and therapy-resistant neuroblastoma
bone regeneration
bone regeneration
protein synthesis
mantle cell lymphoma
E2F1 expression
lung cancer cell growth; angiogenesis; adipocyte differentiation; B cell development
anti-angiogenic connective tissue growth factor (CTGF)
bone regeneration; anti-angiogenic thrombospondin-1 (Tsp1)
apoptosis; E2F1 protein regulation
mantle cell lymphoma
T cell leukaemia; MYCN target
granulopoiesis; mouse embryogenesis; hormones temporal regulation
bone regeneration; cell cycle progression and anchorage-independent growth cells
granulopoiesis; TRAIL-induced apoptotic signalin; cell proliferation
granulopoiesis; bone regeneration; HMGA2 and cell proliferation
angiogenesis
cell cycle arrest; cell death
TLR4 expression; epithelial immune responses
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
granulopoiesis; mouse embryogenesis; hormones temporal regulation
adipocyte differentiation; tumor markers
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
caspases cascade; cell growth
target gene Hoxb8a
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
SCN; circadian clock regulation
involvement of the HIF signaling pathway; Endothelial Cell Response to Hypoxia; Receptor Tyrosine Kinase Ligand Ephrin-A3 inhibition
autoimmunity
limb development; myeloid differentiation of HL60 cells; regulation of HOXB8 expression
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
Regulatory interaction of HNF1-alpha; intestinal epithelial cell differentiation
Regulatory interaction of HNF1-alpha; intestinal epithelial cell differentiation
glioblastoma; Akt pathway
human breast cancer; ovarian cancer; ; midbrain-hindbrain boundary
innate immune responses
innate immune responses
skeletal muscle proliferation and differentiation; heart development and physiology
skeletal muscle proliferation and differentiation; mesoderm formation; cardiac muscle progenitors
skeletal muscle proliferation and differentiation; heart development and physiology
skeletal muscle proliferation and differentiation; mesoderm formation; cardiac muscle progenitors
muscle differentiation; skeletal muscle development; targets the human estrogen receptor-alpha; muscular hypertrophy of Texel sheep; a suppressor of breast cancer metastasis
skeletal muscle proliferation and differentiation; heart development and physiology
muscle differentiation; skeletal muscle development; targets the human estrogen receptor-alpha; muscular hypertrophy of Texel sheep; a suppressor of breast cancer metastasis
T cell leukaemia; MYCN target
lung cancer cell growth; angiogenesis; adipocyte differentiation; B cell development
anti-angiogenic connective tissue growth factor (CTGF)
bone regeneration; anti-angiogenic thrombospondin-1 (Tsp1)
apoptosis; E2F1 protein regulation
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
mantle cell lymphoma
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
thyroid carcinogenesis; Osteogenic differentiation of human adipose tissue-derived stem cells
granulopoiesis; mouse embryogenesis; hormones temporal regulation
bone regeneration; cell cycle progression and anchorage-independent growth cells
granulopoiesis; TRAIL-induced apoptotic signalin; cell proliferation
granulopoiesis; bone regeneration; HMGA2 and cell proliferation
angiogenesis
cell cycle arrest; cell death
TLR4 expression; epithelial immune responses
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
cell cycle alterations; protein synthesis; chemosensitivity of tumor cells
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
retinoic-acid-induced neuronal differentiation of NT2 cells
retinoic-acid-induced neuronal differentiation of NT2 cells
T cell leukaemia; MYCN target
lung cancer cell growth; angiogenesis; adipocyte differentiation; B cell development
anti-angiogenic connective tissue growth factor (CTGF)
bone regeneration; anti-angiogenic thrombospondin-1 (Tsp1)
apoptosis; E2F1 protein regulation
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
mantle cell lymphoma
skeletal muscle proliferation and differentiation; mesoderm formation; cardiac muscle progenitors
skeletal muscle proliferation and differentiation; heart development and physiology
skeletal muscle proliferation and differentiation; mesoderm formation; cardiac muscle progenitors
muscle differentiation; skeletal muscle development; targets the human estrogen receptor-alpha; muscular hypertrophy of Texel sheep; a suppressor of breast cancer metastasis
skeletal muscle proliferation and differentiation; heart development and physiology
skeletal muscle proliferation and differentiation; mesoderm formation; cardiac muscle progenitors
muscle differentiation; skeletal muscle development; targets the human estrogen receptor-alpha; muscular hypertrophy of Texel sheep; a suppressor of breast cancer metastasis
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
thyroid carcinogenesis; cell growth inhibition; HIV-1 latency
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
innate immune responses
human breast cancer; ovarian cancer; ; midbrain-hindbrain boundary
lung cancer cell growth; angiogenesis; adipocyte differentiation; B cell development
anti-angiogenic connective tissue growth factor (CTGF)
bone regeneration; anti-angiogenic thrombospondin-1 (Tsp1)
apoptosis; E2F1 protein regulation
mantle cell lymphoma
downregulation of the proto-oncogene BCL6
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
cell growth inhibition
innate immune responses
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
bone regeneration; anti-angiogenic thrombospondin-1 (Tsp1)
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
breast cancer
downregulation of the proto-oncogene BCL6
epithelial to mesenchymal transition
epithelial to mesenchymal transition
post-transcriptional repression of ZFHX1B
expression of E-cadherin; expression of transcription factor 8
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
T cell leukaemia; MYCN target
skeletal muscle differentiation; erythropoiesis; cell growth
retinoic-acid-induced neuronal differentiation of NT2 cells
skeletal muscle differentiation; erythropoiesis; cell growth
breast cancer
epithelial to mesenchymal transition
epithelial to mesenchymal transition
post-transcriptional repression of ZFHX1B
expression of E-cadherin; expression of transcription factor 8
epithelial to mesenchymal transition; targeting ZEB1 and SIP1
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
human breast cancer; ovarian cancer; ; midbrain-hindbrain boundary
human breast cancer; ovarian cancer; ; midbrain-hindbrain boundary
human breast cancer; ovarian cancer; ; midbrain-hindbrain boundary
human breast cancer; ovarian cancer; ; midbrain-hindbrain boundary
human breast cancer; ovarian cancer; ; midbrain-hindbrain boundary
lung cancer cell growth; angiogenesis; adipocyte differentiation; B cell development
anti-angiogenic connective tissue growth factor (CTGF)
bone regeneration; anti-angiogenic thrombospondin-1 (Tsp1)
apoptosis; E2F1 protein regulation
mantle cell lymphoma
lung cancer cell growth; angiogenesis; adipocyte differentiation; B cell development
anti-angiogenic connective tissue growth factor (CTGF)
bone regeneration; anti-angiogenic thrombospondin-1 (Tsp1)
apoptosis; E2F1 protein regulation
mantle cell lymphoma
human breast cancer; ovarian cancer; ; midbrain-hindbrain boundary
prostate cancer; targets of p53; cell proliferation and adhesion-independent growth; colorectal cancer
prostate cancer; targets of p53; cell proliferation and adhesion-independent growth; colorectal cancer
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
diabetic kidney glomeruli; inhibition of E-box repressors; cell growth
colorectal cancer; targets FLJ21308
granulopoiesis; mouse embryogenesis; hormones temporal regulation; bone regeneration; cell cycle progression and anchorage-independent growth cells; HMGA2 and cell proliferation
granulopoiesis; mouse embryogenesis; hormones temporal regulation
bone regeneration; cell cycle progression and anchorage-independent growth cells
granulopoiesis; TRAIL-induced apoptotic signalin; cell proliferation
granulopoiesis; bone regeneration; HMGA2 and cell proliferation
angiogenesis
cell cycle arrest; cell death
TLR4 expression; epithelial immune responses
regulation of IKKbeta; ovarian cancer
human ovarian cancer; cell survival and cisplatin resistance; Hedgehog signaling to specify muscle cell fat
involvement of the HIF signaling pathway; Endothelial Cell Response to Hypoxia; Receptor Tyrosine Kinase Ligand Ephrin-A3 inhibition
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
epithelial to mesenchymal transition
epithelial to mesenchymal transition
post-transcriptional repression of ZFHX1B
expression of E-cadherin; expression of transcription factor 8
epithelial to mesenchymal transition
epithelial to mesenchymal transition
post-transcriptional repression of ZFHX1B
expression of E-cadherin; expression of transcription factor 8
cell cycle arrest;cell death;
granulopoiesis;mouse embryogenesis;hormones temporal regulation;bone regeneration;cell cycle progression and anchorage-independent growth cells;HMGA2 and cell proliferation
granulopoiesis;mouse embryogenesis;hormones temporal regulation;bone regeneration;cell cycle progression and anchorage-independent growth cells;HMGA2 and cell proliferation
granulopoiesis;mouse embryogenesis;hormones temporal regulation;bone regeneration;cell cycle progression and anchorage-independent growth cells;HMGA2 and cell proliferation
granulopoiesis;mouse embryogenesis;hormones temporal regulation;bone regeneration;cell cycle progression and anchorage-independent growth cells;HMGA2 and cell proliferation
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
granulopoiesis; mouse embryogenesis; hormones temporal regulation; bone regeneration; cell cycle progression and anchorage-independent growth cells; HMGA2 and cell proliferation
granulopoiesis; mouse embryogenesis; hormones temporal regulation; bone regeneration; cell cycle progression and anchorage-independent growth cells; HMGA2 and cell proliferation
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
epithelial to mesenchymal transition
epithelial to mesenchymal transition
na
na
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
granulopoiesis; mouse embryogenesis; hormones temporal regulation
TLR4 expression; epithelial immune responses
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
cell cycle alterations; protein synthesis; chemosensitivity of tumor cells
T cell leukaemia; MYCN target
granulopoiesis; mouse embryogenesis; hormones temporal regulation
TLR4 expression; epithelial immune responses
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
cell cycle alterations; protein synthesis; chemosensitivity of tumor cells
T cell leukaemia; MYCN target
retinoic-acid-induced neuronal differentiation of NT2 cells
granulopoiesis; bone regeneration; HMGA2 and cell proliferation
protein synthesis
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
glioblastoma; Akt pathway
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
adipocyte differentiation; tumor markers
adipocyte differentiation; tumor markers
colorectal cancer; targets FLJ21308
colorectal cancer; targets FLJ21308
innate immune responses
innate immune responses
innate immune responses
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
adipocyte differentiation; tumor markers
adipocyte differentiation; tumor markers
colorectal cancer; targets FLJ21308
colorectal cancer; targets FLJ21308
colorectal cancer; targets FLJ21308
SCN; circadian clock regulation
SCN; circadian clock regulation
SCN; circadian clock regulation
prostate cancer; targets of p53; cell proliferation and adhesion-independent growth; colorectal cancer
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
erythropoiesis inhibition; cancerous growth; paramutation; angiogenesis; non-small cell lung cancer; bone regeneration; melanoma progression
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
granulopoiesis; mouse embryogenesis; hormones temporal regulation; bone regeneration; cell cycle progression and anchorage-independent growth cells; HMGA2 and cell proliferation
skeletal muscle proliferation and differentiation; mesoderm formation; cardiac muscle progenitors
human breast cancer; ovarian cancer; ; midbrain-hindbrain boundary
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
prostate cancer; targets of p53; cell proliferation and adhesion-independent growth; colorectal cancer
thyroid carcinogenesis; cell growth inhibition; HIV-1 latency
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
skeletal muscle proliferation and differentiation; heart development and physiology
skeletal muscle proliferation and differentiation; heart development and physiology
skeletal muscle proliferation and differentiation; mesoderm formation; cardiac muscle progenitors
muscle differentiation; skeletal muscle development; targets the human estrogen receptor-alpha; muscular hypertrophy of Texel sheep; a suppressor of breast cancer metastasis
innate immune responses
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
bone regeneration; anti-angiogenic thrombospondin-1 (Tsp1
anti-angiogenic connective tissue growth factor (CTGF)
innate immune responses
epithelial to mesenchymal transition
epithelial to mesenchymal transition
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
HIV-1 latency; osteoclast differentiation; granulocytic differentiantion
innate immune responses
skeletal muscle differentiation; erythropoiesis; cell growth
skeletal muscle differentiation; erythropoiesis; cell growth
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
apoptosis; cell cycle progression; granulopoiesis; mesoderm development; pancreas regeneration
cell cycle alterations; protein synthesis; chemosensitivity of tumor cells
HIV-1 latency; osteoclast differentiation; granulocytic differentiantion
lung cancer cell growth; angiogenesis; adipocyte differentiation; B cell development
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
thyroid carcinogenesis; cell growth inhibition; HIV-1 latency
lung cancer cell growth;angiogenesis ;adipocyte differentiation;B cell development
apoptosis; E2F1 protein regulation
anti-angiogenic connective tissue growth factor (CTGF)
mantle cell lymphoma
T cell leukaemia; MYCN target
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
cell cycle alterations; protein synthesis; chemosensitivity of tumor cells
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
SCN; circadian clock regulation
granulopoiesis; mouse embryogenesis; hormones temporal regulation
bone regeneration; cell cycle progression and anchorage-independent growth cells
granulopoiesis; TRAIL-induced apoptotic signalin; cell proliferation
granulopoiesis; bone regeneration; HMGA2 and cell proliferation
angiogenesis
cell cycle arrest; cell death
TLR4 expression; epithelial immune responses
retinoic-acid-induced neuronal differentiation of NT2 cells
breast cancer
muscle differentiation; skeletal muscle development; targets the human estrogen receptor-alpha; muscular hypertrophy of Texel sheep; a suppressor of breast cancer metastasis
skeletal muscle proliferation and differentiation; heart development and physiology
skeletal muscle proliferation and differentiation; heart development and physiology
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
skeletal muscle proliferation and differentiation; heart development and physiology
cell growth inhibition
SCN; circadian clock regulation
innate immune responses
post-transcriptional repression of ZFHX1B
retinoic-acid-induced neuronal differentiation of NT2 cells
breast cancer
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
caspases cascade; cell growth
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
retinoic-acid-induced neuronal differentiation of NT2 cells
breast cancer
granulopoiesis; mouse embryogenesis; hormones temporal regulation
bone regeneration; cell cycle progression and anchorage-independent growth cells
granulopoiesis; TRAIL-induced apoptotic signalin; cell proliferation
granulopoiesis; bone regeneration; HMGA2 and cell proliferation
angiogenesis
cell cycle arrest; cell death
TLR4 expression; epithelial immune responses
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
MYCN oncogene; p53-induced apoptosis in prostate cancer; downregulation of CCND1 and CDK6; apoptosis; cell cycle arrest, and senescence; a suppressor of neuroblastoma tumorigenesis; tumor suppressor in neuroblastoma cells
proliferation of breast cancer cells; growth of MYCN-amplified and therapy-resistant neuroblastoma
apoptosis; E2F1 protein regulation
bone regeneration
T cell leukaemia; MYCN target
E2F1 posttranscriptional regulation; E2F1 posttranscriptional regulation; development of TGFbeta resistance in gastric cancerp
E2F1 expression
lung cancer cell growth; angiogenesis; adipocyte differentiation; B cell development
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
lung cancer; Tcl1 expression; Mcl-1 protein expression and apoptosis
epithelial to mesenchymal transition; targeting ZEB1 and SIP1
epithelial to mesenchymal transition
post-transcriptional repression of ZFHX1B
expression of E-cadherin; expression of transcription factor 8
apoptosis; cells anchorage-independent growth; mmune response; cancer cell growth, migration, and invasion; chemosensitivity of tumor cells; self-renewal of mouse ES cells
epithelial to mesenchymal transition
post-transcriptional repression of ZFHX1B
expression of E-cadherin; expression of transcription factor 8
epithelial to mesenchymal transition; targeting ZEB1 and SIP1
na
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
SP synthesis and release in the neuronal cells
T cell leukaemia; MYCN target
T cell leukaemia; MYCN target
T cell leukaemia; MYCN target
T cell leukaemia; MYCN target
T cell leukaemia; MYCN target
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
expression of E-cadherin; expression of transcription factor 8
granulopoiesis; mouse embryogenesis; hormones temporal regulation
bone regeneration; cell cycle progression and anchorage-independent growth cells
granulopoiesis; TRAIL-induced apoptotic signalin; cell proliferation
granulopoiesis; bone regeneration; HMGA2 and cell proliferation
angiogenesis
cell cycle arrest; cell death
TLR4 expression; epithelial immune responses
innate immune response; B cells differentiation; expression of TP53INP1; activation of caspases cascade; vascular inflammation and diseases
Mir-1 and miR-200 were reduced with progression of prostate adenocarcinoma, and we identify Slug as one of the phylogenetically conserved targets of these miRs. The authors demonstrate that SLUG is a direct repressor of miR-1 and miR-200 transcription. Thus, SLUG and miR-1/miR-200 act in a self-reinforcing regulatory loop, leading to amplification of EMT.
Mir-1 and miR-200 were reduced with progression of prostate adenocarcinoma, and we identify Slug as one of the phylogenetically conserved targets of these miRs. The authors demonstrate that SLUG is a direct repressor of miR-1 and miR-200 transcription. Thus, SLUG and miR-1/miR-200 act in a self-reinforcing regulatory loop, leading to amplification of EMT.
Mir-1 and miR-200 were reduced with progression of prostate adenocarcinoma, and we identify Slug as one of the phylogenetically conserved targets of these miRs. The authors demonstrate that SLUG is a direct repressor of miR-1 and miR-200 transcription. Thus, SLUG and miR-1/miR-200 act in a self-reinforcing regulatory loop, leading to amplification of EMT.
Mir-1 and miR-200 were reduced with progression of prostate adenocarcinoma, and we identify Slug as one of the phylogenetically conserved targets of these miRs. The authors demonstrate that SLUG is a direct repressor of miR-1 and miR-200 transcription. Thus, SLUG and miR-1/miR-200 act in a self-reinforcing regulatory loop, leading to amplification of EMT.
granulopoiesis; mouse embryogenesis; hormones temporal regulation
miR-196b expression was significantly repressed by ETS2 during gastric cancer oncogenesis.
Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells.
pri-miR-216a is activated transcriptionally by the androgen pathway in a ligand-dependent manner and is further enhanced by the hepatitis B virus X protein.
miR-17/92cluster is under control of the key mammary transcription factor STAT5
miR-17/92cluster is under control of the key mammary transcription factor STAT5
miR-17/92cluster is under control of the key mammary transcription factor STAT5
miR-17/92cluster is under control of the key mammary transcription factor STAT5
miR-17/92cluster is under control of the key mammary transcription factor STAT5
miR-17/92cluster is under control of the key mammary transcription factor STAT5
SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA.
SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA.
Both P300 and PCAF act as cofactors for ZEB1, forming a P300/PCAF/ZEB1 complex on the miR200c/141 promoter. This binding results in lysine acetylation of ZEB1 and a release of ZEB1 suppression on miR-200c/141 transcription.
Both P300 and PCAF act as cofactors for ZEB1, forming a P300/PCAF/ZEB1 complex on the miR200c/141 promoter. This binding results in lysine acetylation of ZEB1 and a release of ZEB1 suppression on miR-200c/141 transcription.
Both P300 and PCAF act as cofactors for ZEB1, forming a P300/PCAF/ZEB1 complex on the miR200c/141 promoter. This binding results in lysine acetylation of ZEB1 and a release of ZEB1 suppression on miR-200c/141 transcription.
Both P300 and PCAF act as cofactors for ZEB1, forming a P300/PCAF/ZEB1 complex on the miR200c/141 promoter. This binding results in lysine acetylation of ZEB1 and a release of ZEB1 suppression on miR-200c/141 transcription.
Both P300 and PCAF act as cofactors for ZEB1, forming a P300/PCAF/ZEB1 complex on the miR200c/141 promoter. This binding results in lysine acetylation of ZEB1 and a release of ZEB1 suppression on miR-200c/141 transcription.
Both P300 and PCAF act as cofactors for ZEB1, forming a P300/PCAF/ZEB1 complex on the miR200c/141 promoter. This binding results in lysine acetylation of ZEB1 and a release of ZEB1 suppression on miR-200c/141 transcription.
The authors conclude that MYCN contributes to neuroblastoma cell migration and invasion, by directly down-regulating miR-335, resulting in the up-regulation of the TGF-�?signalling pathway members ROCK1, MAPK1, and putative member LRG1, which positively promote this process.
EPAC proteins control miR-124 transcription in the brain for processing spatial learning and social interactions.
NFkb activation suppressed miR-199a2/214 transcription, and this suppression was reversed by NFkb inhibition in HCC cells.
NFkb activation suppressed miR-199a2/214 transcription, and this suppression was reversed by NFkb inhibition in HCC cells.
pecific miRNAs (miR-181a, miR-519a, miR-374a and miR-630) are critical downstream targets of the p63.
pecific miRNAs (miR-181a, miR-519a, miR-374a and miR-630) are critical downstream targets of the p63.
pecific miRNAs (miR-181a, miR-519a, miR-374a and miR-630) are critical downstream targets of the p63.
pecific miRNAs (miR-181a, miR-519a, miR-374a and miR-630) are critical downstream targets of the p63.
adipocyte differentiation; tumor markers
The let-7a-3/let-7b promoter is highly responsive to NFkB.
KLF2 binds to the promoter and induces a significant upregulation of the miR-143/145 cluster.
KLF2 binds to the promoter and induces a significant upregulation of the miR-143/145 cluster.
directly activate miR-21 transcription
YY1 and mir-1 form a regulation loop.
miR-103-1 (host gene Pank3), miR-148b (Copz1), miR-182/96/183, miR-205 and miR-378 (Ppargc1b) are activated by Pparg in 3T3-L1 adipocytes.
miR-103-1 (host gene Pank3), miR-148b (Copz1), miR-182/96/183, miR-205 and miR-378 (Ppargc1b) are activated by Pparg in 3T3-L1 adipocytes.
miR-103-1 (host gene Pank3), miR-148b (Copz1), miR-182/96/183, miR-205 and miR-378 (Ppargc1b) are activated by Pparg in 3T3-L1 adipocytes.
miR-103-1 (host gene Pank3), miR-148b (Copz1), miR-182/96/183, miR-205 and miR-378 (Ppargc1b) are activated by Pparg in 3T3-L1 adipocytes.
miR-103-1 (host gene Pank3), miR-148b (Copz1), miR-182/96/183, miR-205 and miR-378 (Ppargc1b) are activated by Pparg in 3T3-L1 adipocytes.
miR-103-1 (host gene Pank3), miR-148b (Copz1), miR-182/96/183, miR-205 and miR-378 (Ppargc1b) are activated by Pparg in 3T3-L1 adipocytes.
miR-103-1 (host gene Pank3), miR-148b (Copz1), miR-182/96/183, miR-205 and miR-378 (Ppargc1b) are activated by Pparg in 3T3-L1 adipocytes.
repress miR-200-family
repress miR-200-family
repress miR-200-family
NF-kb was found to bind the promoters of all four miRNAs (miR-10b, miR-17, miR-21 and miR-9) to suppress their expression at the transcriptional level.
NF-kb was found to bind the promoters of all four miRNAs (miR-10b, miR-17, miR-21 and miR-9) to suppress their expression at the transcriptional level.
NF-kb was found to bind the promoters of all four miRNAs (miR-10b, miR-17, miR-21 and miR-9) to suppress their expression at the transcriptional level.
NF-kb was found to bind the promoters of all four miRNAs (miR-10b, miR-17, miR-21 and miR-9) to suppress their expression at the transcriptional level.
TGF-b1 down-regulates miR-192 and miR-194, co-transcribed in the shared precursor pri-miR-192/194. Luciferase reporter analysis showed constitutive promoter activity within nucleotides +21 to -223.
TGF-b1 down-regulates miR-192 and miR-194, co-transcribed in the shared precursor pri-miR-192/194. Luciferase reporter analysis showed constitutive promoter activity within nucleotides +21 to -223.
The authors identified Hepatocyte Nuclear Factor and p53 binding sites within this region that were required for constitutive promoter activity, which was decreased by TGF-b1 via an Alk5-dependent mechanism.
The authors identified Hepatocyte Nuclear Factor and p53 binding sites within this region that were required for constitutive promoter activity, which was decreased by TGF-b1 via an Alk5-dependent mechanism.
The authors identified Hepatocyte Nuclear Factor and p53 binding sites within this region that were required for constitutive promoter activity, which was decreased by TGF-b1 via an Alk5-dependent mechanism.
The authors identified Hepatocyte Nuclear Factor and p53 binding sites within this region that were required for constitutive promoter activity, which was decreased by TGF-b1 via an Alk5-dependent mechanism.
activate its transcription
transcriptional repression
ER-beta downregulates miR-30a by binding to two specific sites proximal to the gene.
promote the miRNA
promote the miRNA
promote the miRNA
Using the promoter reporter assay and chromatin immunoprecipitation, activator protein-1 (AP-1) was shown to bind to the microRNA-29b-1 promoter.
Using the promoter reporter assay and chromatin immunoprecipitation, activator protein-1 (AP-1) was shown to bind to the microRNA-29b-1 promoter.
MicroRNA-34a (miR-34a), a transcriptional target of p53
myogenin transactivate miR-133
myogenin transactivate miR-133
myogenin transactivate miR-133
Transcriptional regulation of miR-224 upregulated in human HCCs by NFkb.
Ad-IRF3 suppressed the expression of microRNA-155 and its star-form partner miR-155*
p73 drives the expression of miR-34a, but not miR-34b and c, in mouse cortical neurons.
Bioinformatics predicted that the let-7g promoter has a binding site for the transcriptional repressor OCT-1. We used a promoter assay and chromatin immunoprecipitation to confirm this binding.
Bioinformatics predicted that the let-7g promoter has a binding site for the transcriptional repressor OCT-1. We used a promoter assay and chromatin immunoprecipitation to confirm this binding.
The transcription factors SNAIL and ZEB1 bound to E-boxes in the miR-34a/b/c promoters, thereby repressing miR-34a and miR-34b/c expression.
The transcription factors SNAIL and ZEB1 bound to E-boxes in the miR-34a/b/c promoters, thereby repressing miR-34a and miR-34b/c expression.
The transcription factors SNAIL and ZEB1 bound to E-boxes in the miR-34a/b/c promoters, thereby repressing miR-34a and miR-34b/c expression.
The transcription factors SNAIL and ZEB1 bound to E-boxes in the miR-34a/b/c promoters, thereby repressing miR-34a and miR-34b/c expression.
miR-125a-3p/5p were found to be TLR2 responsive.
miR-155 transactivation in infection was regulated by NF-kb p65
STAT3 binds to the promoter region of miR-125b in vitro and serves as a transactivator.
The authors identified p73 as transcriptional regulator of miR-143/145 during neutrophil differentiation of APL cells.
The authors identified p73 as transcriptional regulator of miR-143/145 during neutrophil differentiation of APL cells.
DDX5 regulated a subset of MicroRNAs including miR-21 and miR-182 in basal breast cancer cells.
DDX5 regulated a subset of MicroRNAs including miR-21 and miR-182 in basal breast cancer cells.
The authors identified a single hypermethylated CpG site in the promoter region of miR-34c gene that contributed to transcriptional repression of miR-34c in BT-ICs by reducing DNA binding activities of Sp1.
Sox10 activate mir-338
miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells.
miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells.
The expression of miR-135b and its host gene LEMD1 through activation of signal transducer and activator of transcription (STAT) 3.
miR-34 miRNAs are p53 targets
miR-34 miRNAs are p53 targets
miR-34 miRNAs are p53 targets
Smad3 directly binds to a Smad-binding element located in the promoter region of miR-200b/a, where it functions as a transcriptional activator.
Smad3 directly binds to a Smad-binding element located in the promoter region of miR-200b/a, where it functions as a transcriptional activator.
beta-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin-signaling pathway.
beta-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin-signaling pathway.
beta-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin-signaling pathway.
beta-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin-signaling pathway.
beta-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin-signaling pathway.
beta-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin-signaling pathway.
XBP1 induces microRNA-346 expression
The DNA methyltransferase inhibitor (5-aza-2-deoxycytidine) and the histone deacetylase inhibitor [trichostatin A (TSA)] both significantly up-regulated miR-146a transcriptional activation by altering the DNA-binding activity of NF-kb in macrophages isolated from aged mice
transactivate
In human prostate cancer cells, Myc negatively regulates miR-26a and miR-26b via direct binding to their parental Pol II gene promoters.
In human prostate cancer cells, Myc negatively regulates miR-26a and miR-26b via direct binding to their parental Pol II gene promoters.
MicroRNA-34a (miR-34a) is a transcriptional target of p53 and is down-regulated in pancreatic cancer.
MYC protein inhibits transcription of the microRNA cluster MC-let-7a-1~let-7d via noncanonical E-box.
MYC protein inhibits transcription of the microRNA cluster MC-let-7a-1~let-7d via noncanonical E-box.
MYC protein inhibits transcription of the microRNA cluster MC-let-7a-1~let-7d via noncanonical E-box.
CDX2, a homeobox transcription factor, binds to promoter regions of the miR-125b gene and activates transcriptional regulation of miR-125b in malignant myeloid cells.
The transcription factor PU.1 induces the secondary determinant Egr2 which, in turn, directly represses miR-17-92 expression by recruiting histone demethylase Jarid1b leading to histone H3 lysine K4 demethylation within the CpG island at the miR-17-92 promoter.
The transcription factor PU.1 induces the secondary determinant Egr2 which, in turn, directly represses miR-17-92 expression by recruiting histone demethylase Jarid1b leading to histone H3 lysine K4 demethylation within the CpG island at the miR-17-92 promoter.
The transcription factor PU.1 induces the secondary determinant Egr2 which, in turn, directly represses miR-17-92 expression by recruiting histone demethylase Jarid1b leading to histone H3 lysine K4 demethylation within the CpG island at the miR-17-92 promoter.
The transcription factor PU.1 induces the secondary determinant Egr2 which, in turn, directly represses miR-17-92 expression by recruiting histone demethylase Jarid1b leading to histone H3 lysine K4 demethylation within the CpG island at the miR-17-92 promoter.
The transcription factor PU.1 induces the secondary determinant Egr2 which, in turn, directly represses miR-17-92 expression by recruiting histone demethylase Jarid1b leading to histone H3 lysine K4 demethylation within the CpG island at the miR-17-92 promoter.
The transcription factor PU.1 induces the secondary determinant Egr2 which, in turn, directly represses miR-17-92 expression by recruiting histone demethylase Jarid1b leading to histone H3 lysine K4 demethylation within the CpG island at the miR-17-92 promoter.
The authors found that visual experience regulated histone post-translational modifications at a CRE locus that is important for miR-212 and miR-132 cluster transcription.
The authors found that visual experience regulated histone post-translational modifications at a CRE locus that is important for miR-212 and miR-132 cluster transcription.
miR-135a was transcribed by forkhead box M1 (FOXM1)
MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1) in adult liver and controls expression of frizzled-6.
p300 regulates miR-146a
mir-140 is activated by sox9
CREB1 is the transactivator protein of mir-132
FOSL1 (also known as Fra-1) directly stimulated the transcription of miR-221/222
FOSL1 (also known as Fra-1) directly stimulated the transcription of miR-221/222
the cell cycle regulatory transcription factor E2F1 induces miR-449.
the cell cycle regulatory transcription factor E2F1 induces miR-449.
the cell cycle regulatory transcription factor E2F1 induces miR-449.
miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer.
The authors demonstrate that direct repression of let-7a by EWS-FLI-1 participates in the tumorigenic potential of ESFT cells in vivo.
HDAC4 activates mir-200a
NDY1 and EZH2 repress miR-101 by binding its promoter in concert, via a process triggered by upregulation of NDY1.
NDY1 and EZH2 repress miR-101 by binding its promoter in concert, via a process triggered by upregulation of NDY1.
Moreover, we show that in SSC-enriched germ cell cultures, miR-21 is regulated by the transcription factor ETV5, known to be critical for SSC self-renewal.
FOXP3 also induces two miRs, miR-7 and miR-155.
FOXP3 also induces two miRs, miR-7 and miR-155.
The manipulation of Ets-1 levels strongly affected miR-146a promoter activity in vitro
PU.1 directly controls expression of of miR-146a, miR-342, miR-338, and miR-155
PU.1 directly controls expression of of miR-146a, miR-342, miR-338, and miR-155
PU.1 directly controls expression of of miR-146a, miR-342, miR-338, and miR-155
PU.1 directly controls expression of of miR-146a, miR-342, miR-338, and miR-155
In pancreatic beta cells, c-Rel and p65 of the NF-kB family activated the mir21 gene promoter and increased miR-21 RNA levels
In pancreatic beta cells, c-Rel and p65 of the NF-kB family activated the mir21 gene promoter and increased miR-21 RNA levels
STAT3 suppresses expression of miR-21
SMAD3 and SMAD4 activates
SMAD3 and SMAD4 activates
SMAD3 and SMAD4 activates
SMAD3 and SMAD4 activates
n/a
n/a
The proto-oncogene ETS-1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR-222 by direct binding to its promoter region.
The miR-143/145 cluster is a novel transcriptional target of Jagged-1/Notch
The miR-143/145 cluster is a novel transcriptional target of Jagged-1/Notch
The transcription factor FOSL1 (also known as Fra-1), which is found in basal-like breast cancers but not in the luminal subtype, stimulated the transcription of miR-221/222.
Both TGF-beta and BMP4 activate transcription of the miR-143/145 gene cluster through the CArG box.
Both TGF-beta and BMP4 activate transcription of the miR-143/145 gene cluster through the CArG box.
The transcription factors Max and RXR alpha bind directly to the miR-193a promoter and inhibit miR-193a expression during transformation.
The transcription factors Max and RXR alpha bind directly to the miR-193a promoter and inhibit miR-193a expression during transformation.
Cancerous tissues showed significantly lower Sp1-binding affinity to the miR-132 promoter, relative to non-tumor samples.
HMGA1 directly binds to the proximal promoter of miR-222 in NSCLC cells.
Expression of miR-10b and its transcription factor Twist are up-regulated by thrombin
miRNA-210 (miR-210) is a direct transcriptional target of HIF-1,
transcriptional activation of miR-29 is triggered in response to DNA damage and occurs in a p53-dependent manner
The miR-200 family members transactivated by p53 then repress ZEB1/2 expression.
The miR-200 family members transactivated by p53 then repress ZEB1/2 expression.
The miR-200 family members transactivated by p53 then repress ZEB1/2 expression.
p53-regulated miR-192 family members also repress ZEB2 expression.
Deletion mutant analysis of the miR-365 promoter showed that two transcription factors, Sp1 and NF-kB
Deletion mutant analysis of the miR-365 promoter showed that two transcription factors, Sp1 and NF-kB
The authors further identified two EGFR-independent mechanisms that regulate E2F3a expression, namely one, acting by promoter methylation of miR-34a, which by its physical interaction with E2F3a transcripts causes their degradation
the AP-1 site was more important than the NF-kB site for increasing miR-155 in HTR-8/SVneo cells.
MyoD binds in close proximity to the miR-378 gene and causes both transactivation and chromatin remodeling.
E2a tumor suppressor transcriptionally activates the genes encoding miR-451 and miR-709.
E2a tumor suppressor transcriptionally activates the genes encoding miR-451 and miR-709.
MYB can inhibit miR-148a by directly acting on the transcription factor binding site in miR-148a gene and miR-148a can posttranscriptionally silence Bcl-2.
MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E.
MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E.
MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E.
MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E.
miR-193a-5p, a direct p63/p73 transcriptional target which is repressed by p63 and activated by p73 both in vitro and in vivo.
miR-193a-5p, a direct p63/p73 transcriptional target which is repressed by p63 and activated by p73 both in vitro and in vivo.
Jagged2 was found to promote metastasis by increasing the expression of GATA-binding (Gata) factors, which suppressed expression of the microRNA-200 (miR-200) family of microRNAs that target the transcriptional repressors that drive EMT and thereby induced EMT.
Jagged2 was found to promote metastasis by increasing the expression of GATA-binding (Gata) factors, which suppressed expression of the microRNA-200 (miR-200) family of microRNAs that target the transcriptional repressors that drive EMT and thereby induced EMT.
Jagged2 was found to promote metastasis by increasing the expression of GATA-binding (Gata) factors, which suppressed expression of the microRNA-200 (miR-200) family of microRNAs that target the transcriptional repressors that drive EMT and thereby induced EMT.
miR-708 is encoded within an intron of the CHOP-regulated gene Odz4, a member of the highly conserved teneurin family of developmental regulators. Odz4 and mir-708 expression is coregulated by CHOP
GnRH strongly induces the AK006051 gene transcript that encodes two micro-RNAs, miR-132 and miR-212, within the first intron.
GnRH strongly induces the AK006051 gene transcript that encodes two micro-RNAs, miR-132 and miR-212, within the first intron.
9-cis-RA, all-trans-RA,lithium chloride and CEBP�?might play important regulatory roles in let-7a2 gene expression in A549 cells.
Chromatin immunoprecipitation analysis confirmed that hypophosphorylated RNA polymerase II and transcription factor c-Myc physically bind at miRNA promoter.
Chromatin immunoprecipitation analysis confirmed that hypophosphorylated RNA polymerase II and transcription factor c-Myc physically bind at miRNA promoter.
Electrophoretic mobility shift assay and chromatin immunoprecipitation experiments confirmed that Runx2 bound to the promoter of the miR-3960/miR-2861 cluster.
Electrophoretic mobility shift assay and chromatin immunoprecipitation experiments confirmed that Runx2 bound to the promoter of the miR-3960/miR-2861 cluster.